[Research progress on the relationship between gut-liver axis disorder and sepsis].

Sepsis is a life-threatening organ dysfunction caused by an uncontrolled host response to infection. The mechanism of sepsis is extremely complicated and the mortality is still high. Persistent researches provide an important way to break through the "bottleneck" of clinical diagnosis and treatment of sepsis. In recent years, more and more studies have shown that gut-liver axis disorders, especially those caused by intestinal dysbiosis, intestinal barrier dysfunction, abnormal liver immune function, and bile acid metabolism disorders, play an important role in the occurrence and development of sepsis. This review describes the research progress of gut-liver axis disorders in the pathogenesis of sepsis for providing new ideas for clinical treatment.

Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial.

Objective: Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients. Methods: We conducted a prospective, single-center, double-blind randomized controlled trial in elderly patients aged ≥65 years with ASA I-II. Subjects were randomly assigned to the lidocaine group (Group L, n=70), who received IV 1.5 mg kg-1 lidocaine followed by a continuous infusion of 4 mg kg-1 h-1 lidocaine, or the normal saline group (Group N, n=70), who received an equal volume of saline in the same way. Results: IV lidocaine reduced the total and maintenance propofol dose in Group L (p<0.001), with no significant effect on the induction dose. The incidence of intraoperative hypoxia (p=0.035), emergency airway management events (p=0.005), duration of gastroscopy (p<0.05), consciousness recovery time (p<0.001), and postoperative pain (p=0.009) were all reduced in Group L. Patient (p=0.025) and gastroscopist (p=0.031) satisfaction was higher in Group L. Intraoperative hemodynamic parameters, the respiratory rate, the incidence of sedation-related events and anesthesiologist satisfaction were similar between the two groups. Conclusion: IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction.

Preparation of highly sensitive electrochemical sensor for detection of nitrite in drinking water samples.

Nitrite is both an environmental contaminant and a food additive. Excessive intake of nitrites not only causes blood diseases, but also has the potential risk of causing cancer. Therefore, rapid detection of nitrite in water is necessary. In this work, we propose an electrochemical sensor for the sensing of nitrite. Glassy carbon electrodes modified with noble metal nanomaterials have been widely used in the preparation of sensors, but the surface properties of noble metals largely affect the sensing performance. This work proposes the biosynthesis of Au nanoparticles using the pollen extract of Lycoris radiata as a reducing agent. Flavonoids rich in pollen can be used as weak reducing agents for the reduction of chloroauric acid, and slowly synthesize uniformly dispersed Au nanoparticles. These Au nanoparticles do not agglomerate because they contain small biological molecules on the surface and can form a homogeneous sensing interface on the electrode surface. The electrochemical sensor assembled with biosynthesized Au nanoparticles provides linear detection of nitrite between 0.01 and 3.8 mM. The sensor also has excellent immunity to interference. In addition, the proposed sensor was also successfully used for the detection of nitrite in drinking water.